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  • Title: Host-parasite interactions and trypanosome morphogenesis: a flagellar pocketful of goodies.
    Author: Gull K.
    Journal: Curr Opin Microbiol; 2003 Aug; 6(4):365-70. PubMed ID: 12941406.
    Abstract:
    Trypanosomes are characterised by the possession of a single flagellum and a subpellicular microtubule cytoskeleton. The flagellum is more than an organelle for motility; its position and polarity along with the sub-pellicular cytoskeleton enables the morphogenesis of a distinct flagellar pocket and the flagellar basal body is responsible for positioning and segregating the kinetoplast--the mitochondrial genome. Recent work has highlighted the molecules and morphogenesis of these cytoskeletal/flagellum structures and how dynamic events, occurring in the flagellar pocket and kinetoplast, are critical for host-parasite interactions.
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