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  • Title: Amino acids and peptides. XVI. Synthesis of N-terminal tetrapeptide analogs of fibrin alpha-chain and their inhibitory effects on fibrinogen/thrombin clotting.
    Author: Kawasaki K, Hirase K, Miyano M, Tsuji T, Iwamoto M.
    Journal: Chem Pharm Bull (Tokyo); 1992 Dec; 40(12):3253-60. PubMed ID: 1294328.
    Abstract:
    N-Terminal tetrapeptide analogs of fibrin alpha-chain were synthesized by the solution method using a new active ester, the ester of the oxime of p-nitroacetophenone, and by the solid-phase method. Their inhibitory effects on fibrinogen/thrombin clotting were examined. Of the synthetic peptides, amide analogs of Gly-Pro-Arg-Pro exhibited a more potent inhibitory effect.
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