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  • Title: [Induction of proto-oncogens c-fos and c-jun expression in BALB/c-3T3 cells by cadmium chloride].
    Author: Lei Y, Liu Y.
    Journal: Sichuan Da Xue Xue Bao Yi Xue Ban; 2003 Apr; 34(2):260-1. PubMed ID: 12947706.
    Abstract:
    OBJECTIVE: This study was aimed to explore the possible carcinogenic mechanisms of cadumium and its related compounds involved at the molecular level. METHODS: We investigated the alternations in expressions of the proto-oncogens c-fos and c-jun in BALB/c-3T3 cells induced by cadmium chloride (CdCl2), using differential RT-PCR protocol. RESULTS: It was found that 2 hours after the cells were exposed to CdCl2, overexpression of an immediate early proto-oncogen c-fos was observed in BALB/c-3T3 cells treated with CdCl2 in concentrations ranging from 5 mumol/ml to 40 mumol/ml, and there was a significant dose-dependent relationship between the concentrations of CdCl2 and the levels of c-fos expression after normalization with beta-actin. In the same way, elevated expression of another immediate early proto-oncogen, c-jun, was induced with CdCl2 in concentrations from 20 to 40 mumol/ml. CONCLUSION: The results seem to indicate that overexpressions of c-fos and c-jun are related to genotoxicity of CdCl2. These results might partly explain the cell transformation and carcinogenesis of cadmium.
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