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  • Title: Hypophosphatemic rickets and osteomalacia in polyostotic fibrous dysplasia.
    Author: Chattopadhyay A, Bhansali A, Mohanty SK, Khandelwal N, Mathur SK, Dash RJ.
    Journal: J Pediatr Endocrinol Metab; 2003; 16(6):893-6. PubMed ID: 12948303.
    Abstract:
    A 17 year-old girl with polyostotic fibrous dysplasia and hypophosphatemia had inappropriately low tubular reabsorption of phosphate. She had radiological evidence of rickets and osteomalacia. The patient showed clinical improvement after treatment with phosphate supplementation, active vitamin D (calcitriol) and alendronate. It is postulated that either a phosphaturic substance elaborated from the dysplastic bone or target-organ (kidney) unresponsiveness may interfere with phosphate reabsorption in the renal tubule.
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