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  • Title: Effect of bradykinin analogues on the B1 receptor of rat ileum.
    Author: Vietinghoff G, Hilscher E, Paegelow I, Reissmann S.
    Journal: Peptides; 2003 Jun; 24(6):931-5. PubMed ID: 12948847.
    Abstract:
    The longitudinal muscle of isolated rat ileum is a sensitive bioassay suitable for testing compounds with antagonistic effects on the B(1) receptor. Bradykinin analogues with replacement of proline by alkyl-substituted phenylalanine at position 7 are effective on this receptor as entire molecules and have a stronger antagonistic effect than on the B(2) receptor. A corresponding desArg(9)-compound has a specific effect on the B(1) receptor and a very high antagonistic potency. [LNMPhe(2)]bradykinin as a compound without any replacement at position 7 or 8 shows antagonistic activity as well.
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