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  • Title: Magnetic resonance imaging of immune cells in inflammation of central nervous system.
    Author: Pirko I, Ciric B, Johnson AJ, Gamez J, Rodriguez M, Macura S.
    Journal: Croat Med J; 2003 Aug; 44(4):463-8. PubMed ID: 12950151.
    Abstract:
    AIM: To develop a novel, magnetic resonance-based method for in vivo cell localization in the central nervous system (CNS) of the animals without sacrificing them. METHODS: Cells were labeled in vivo by intravenous injection of cell marker-specific antibodies covalently bound to ultrasmall superparamagnetic iron oxide particles (USPIO). This enabled the visualization of specific cell types by magnetic resonance microscopy (MRM). RESULTS: USPIOs covalently attached to antibodies affected the contrast in MRM scan, and their accumulation on cells manifested as signal weakening in T2*-weighted images or signal enhancement in T1-weighted images. With this method applied in the experimental autoimmune encephalomyelitis (EAE) murine multiple sclerosis (MS) model, CNS-infiltrating CD4+ T cells were easily visualized with cell-specific MRM. CONCLUSION: MRM with targeted contrast materials can be used to localize CNS-infiltrating lymphocytes of interest. Due to its noninvasive character, this method could potentially be used in human MR imaging as well.
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