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  • Title: Cinchona alkaloid derived ligands in catalytic asymmetric transfer hydrogenation.
    Author: Hartikka A, Modin SA, Andersson PG, Arvidsson PI.
    Journal: Org Biomol Chem; 2003 Jul 21; 1(14):2522-6. PubMed ID: 12956071.
    Abstract:
    A collection of chiral quinuclidine ligands, derived from the Cinchona alkaloids quinine and quinidine, has been evaluated in the catalytic asymmetric transfer hydrogenation of aromatic ketones. It was fond that [IrCl(COD)]2 complexes of the diamines QCI-Amine and QCD-Amine gave the most active catalysts, capable of reducing a range of aromatic ketones with excellent conversions and good enantioselectivities (up to 95% ee). These are the best selectivities reported for ligands based on the quinuclidine core in an asymmetric transformation, and advocate that these ligands, commercially available in both pseudo-enantiomeric forms, will find practical use in this and other catalytic processes.
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