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  • Title: Ultrastructural findings in metastatic bronchioloalveolar carcinoma.
    Author: Tan MA, Teichberg S, Roberts B, Hajdu SI.
    Journal: Ann Clin Lab Sci; 2003; 33(3):289-94. PubMed ID: 12956444.
    Abstract:
    This study was prompted by the recent revision of the definition of bronchioloalveolar carcinoma (BAC) that defines BAC, light microscopically, as a non-invasive carcinoma. Doubt has been raised whether BACs retain certain specific microscopic features after becoming invasive or metastatic. We studied 7 cases of metastatic, non-mucinous BAC by electron microscopy. Of these cases, 5 showed Clara cell granules and 1 revealed lamellar bodies. The remaining case did not show ultrastructural features of BAC. These findings suggest that most BACs retain some of their ultrastructural features after becoming metastatic neoplasms.
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