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  • Title: Elevated carotid artery intima-media thickness levels in individuals who subsequently develop type 2 diabetes.
    Author: Hunt KJ, Williams K, Rivera D, O'Leary DH, Haffner SM, Stern MP, González Villalpando C.
    Journal: Arterioscler Thromb Vasc Biol; 2003 Oct 01; 23(10):1845-50. PubMed ID: 12958039.
    Abstract:
    OBJECTIVE: We examined whether B-mode ultrasound-detected carotid artery intima-media thickness (IMT) was elevated before the onset of clinical diabetes. METHODS AND RESULTS: The study population for these analyses included 1127 nondiabetic participants, 66 prediabetic participants, and 303 diabetic participants with a mean age of 49.8 years who participated in the Mexico City Diabetes Study, a prospective cohort study. Common carotid artery (CCA) and internal carotid artery (ICA) IMTs were measured bilaterally by B-mode ultrasound. Age- and sex-adjusted mean ICA and CCA IMTs were both significantly higher among prediabetic individuals [0.81 mm [95% confidence interval (CI), 0.75-0.88] and 0.72 mm [95% CI, 0.69-0.75], respectively] than in individuals who remained free of diabetes [0.71 mm (95% CI, 0.69-0.72) and 0.69 mm (95% CI, 0.68-0.69), respectively]. However, after adjustment for established cardiovascular risk factors, ICA IMT, but not CCA IMT, remained significantly higher among prediabetic individuals [0.81 mm (95% CI, 0.75-0.88) and 0.71 mm (95% CI, 0.68-0.74)] than in individuals who remained free of diabetes [0.71 mm (95% CI, 0.69-0.72) and 0.69 mm (95% CI, 0.68-0.70)]. CONCLUSIONS: The present study provides direct evidence at the vascular level that atherosclerosis levels are elevated before the clinical onset of diabetes.
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