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  • Title: ATRP synthesis of amphiphilic random, gradient, and block copolymers of 2-(dimethylamino)ethyl methacrylate and n-butyl methacrylate in aqueous media.
    Author: Lee SB, Russell AJ, Matyjaszewski K.
    Journal: Biomacromolecules; 2003; 4(5):1386-93. PubMed ID: 12959610.
    Abstract:
    Amphiphilic random, gradient, and block copolymers of 2-(dimethylamino)ethyl methacrylate (DMAEMA) and n-butyl methacrylate (BMA) were synthesized by atom transfer radical polymerization (ATRP) in water/2-propanol mixtures using a methoxy-poly(ethylene glycol) (MPEG) (M(n) = 2000) macroinitiator. Kinetic studies indicate that the copolymerization is well controlled with molecular weights increasing linearly with conversion. Copolymers with molecular weights up to M(n) = 34000 and low polydispersities (M(w)/M(n) = 1.11-1.47) were prepared. The reactivity ratios were calculated for the copolymerizations catalyzed by CuBr/bpy, (r(DMAEMA) = 1.07, r(BMA) = 1.24). The thermosensitivity and aggregation properties of the random, gradient, and block copolymers significantly depended on the architecture of the copolymers. The lower critical solution temperature of MPEG-b-PDMAEMA(84) was 38 degrees C (5 wt % in water).
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