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  • Title: [The role of apoptosis in autoimmune encephalomyelitis].
    Author: Okuda Y, Sakoda S.
    Journal: Nihon Rinsho; 2003 Aug; 61(8):1323-8. PubMed ID: 12962018.
    Abstract:
    Experimental autoimmune encephalomyelitis(EAE), an inflammatory demyelinating disease of the central nervous system(CNS) provoked by myelin antigens, is widely used as a model for multiple sclerosis. Recent studies have shown that apoptosis may contribute to the death of oligodendrocytes and/or neurons, a pathological event leading to neurological deficits. On the other hand, the apoptotic elimination of inflammatory cells such as T cells and macrophages from the CNS is generally believed to contribute to the spontaneous recovery of EAE. Thus, apoptosis is involved in the disease-regulating as well as the disease-promoting processes of EAE.
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