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  • Title: [Effects of isosorbide dinitrate on regional cerebral blood flow and intracranial pressure in cats].
    Author: Ishikawa T, Funatsu N, Nakanishi O, Maekawa T, Sakabe T.
    Journal: No To Shinkei; 1992 Nov; 44(11):1017-20. PubMed ID: 1296713.
    Abstract:
    The effects of isosorbide dinitrate (ISDN) on regional cerebral blood flow (rCBF) and intracranial pressure (ICP) were examined in cats. A low dose of ISDN (2.5 micrograms/kg/min) infusion did not show any changes in cerebral hemodynamics. During high dose of ISDN (5.0 micrograms/kg/min) or NTP (5.0 micrograms/kg/min) infusion, mean blood pressure (mBP) decreased by 10 to 20% accompanied by decreased cerebral perfusion pressure (CPP: mBP-ICP), however, rCBF or ICP did not change. It is concluded that intravenous administrations of ISDN in a dose of 2.5-5.0 micrograms/kg/min that produce slight decrease in blood pressure did not influence on cerebral hemodynamics.
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