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  • Title: Synthesis and biological evaluation of (-)-laulimalide analogues.
    Author: Wender PA, Hegde SG, Hubbard RD, Zhang L, Mooberry SL.
    Journal: Org Lett; 2003 Sep 18; 5(19):3507-9. PubMed ID: 12967311.
    Abstract:
    [reaction: see text] The syntheses of five laulimalide analogues are described, incorporating modifications at the C(16)-C(17)-epoxide, the C(20)-alcohol, as well as the C(1)-C(3)-enoate of the parent natural product. The resultant analogues are active in drug-sensitive HeLa and MDA-MB-435 cell lines. Significantly, like laulimalide, these analogues are poor substrates for the drug transport protein P-glycoprotein (Pgp) and are thus effective against Taxol-resistant cell lines.
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