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  • Title: NmcA carbapenem-hydrolyzing enzyme in Enterobacter cloacae in North America.
    Author: Pottumarthy S, Moland ES, Juretschko S, Swanzy SR, Thomson KS, Fritsche TR.
    Journal: Emerg Infect Dis; 2003 Aug; 9(8):999-1002. PubMed ID: 12967501.
    Abstract:
    An imipenem-resistant Enterobacter cloacae isolate was recovered from the blood of a patient with a hematologic malignancy. Analytical isoelectric focusing, inhibitor studies, hydrolysis, induction assays, and molecular sequencing methods confirmed the presence of a NmcA carbapenem-hydrolyzing enzyme. This first report of NmcA detected in North America warrants further investigation into its distribution and clinical impact.
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