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  • Title: Synergies of microtissue design, viral transduction and adjustable transgene expression for regenerative medicine.
    Author: Kelm JM, Kramer BP, Gonzalez-Nicolini V, Ley B, Fussenegger M.
    Journal: Biotechnol Appl Biochem; 2004 Feb; 39(Pt 1):3-16. PubMed ID: 12968952.
    Abstract:
    In the past decade, regenerative medicine has evolved as an interdisciplinary field, integrating expertise from the medical, life- and material-science communities. Recent advances in tissue engineering, gene therapy, gene-function analysis, animal-free drug testing, drug discovery, biopharmaceutical manufacturing and cell-phenotype engineering have capitalized on a core technology portfolio including artificial microtissue design, viral transduction and precise transcription dosing of therapeutic or phenotype-modulating transgenes. We provide a detailed overview on recent progress in these core technologies and comment on their synergistic impact on current and future human therapies.
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