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  • Title: [Expression of aquaporin - 4 protein in brain from rats with hemorrhagic edema].
    Author: Li YH, Sun SQ.
    Journal: Zhongguo Wei Zhong Bing Ji Jiu Yi Xue; 2003 Sep; 15(9):538-41. PubMed ID: 12971848.
    Abstract:
    OBJECTIVE: To study the expression of aquaporin-4 (AQP4) protein in perihematomal tissue after intracerebral hemorrhage (ICH) in rats. METHODS: The experimental ICH model was established in rats by injecting quantitative collagenase into the left caudate nuclei of the rats. The changes of brain water content (BWC) were measured by the wet and dry weight methods. Immunohistochemistry was used to determine the change of expression of AQP4 protein during different periods after ICH. RESULTS: BWC and AQP4 protein expression in perihematomal tissue were increased at 6 hours after ICH and reached peak at 72 hours. In one week following ICH, it was still higher than normal level. In addition, the expression of AQP4 was positively correlated with BWC (r=0.9857, P<0.01). CONCLUSION: AQP4 has a relevant relationship with the formation of brain edema after ICH.
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