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  • Title: Electrophysiologic evaluation of retinal pigment epithelial damage induced by photic exposure.
    Author: Kawano T, Kato M.
    Journal: Retina; 2003 Aug; 23(4):513-7. PubMed ID: 12972763.
    Abstract:
    PURPOSE: To evaluate the retinal pigment epithelial damage induced by light exposure. METHODS: One eye of 20 rabbits was exposed to xenon light for 2 hours at an irradiance of 140 mW/cm2 at the surface of the cornea. The contralateral eye served as a control. Forty-eight hours after the light exposure, corneal direct-coupled electroretinograms and the 7% NaHCO3 (bicarbonate) responses of the standing potential were recorded. RESULTS: The amplitudes of the a-, b-, and c-waves of the electroretinograms were significantly reduced in the light-exposed eyes, with the c-waves more reduced than the a- and b-waves. The bicarbonate response was also significantly reduced in the irradiated eyes. CONCLUSIONS: The decrease of the bicarbonate response of the standing potential indicated that significant functional damage of the retinal pigment epithelium was induced by the light exposure.
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