These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: 15-Deoxy-delta12,14-PGJ2: endogenous PPARgamma ligand or minor eicosanoid degradation product?
    Author: Powell WS.
    Journal: J Clin Invest; 2003 Sep; 112(6):828-30. PubMed ID: 12975467.
    Abstract:
    15-Deoxy-Delta12,14-prostaglandin J2 (15d-PGJ2) affects gene transcription by activating PPARgamma and by covalent addition to transcription factors and signaling molecules, However, it is not known whether the high concentrations of 15d-PGJ2 required for these responses are consistent with physiological levels. A new study suggests that in vivo 15d-PGJ2 levels are actually several orders of magnitude below the levels required to induce many of the biological effects attributed to this molecule.
    [Abstract] [Full Text] [Related] [New Search]