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  • Title: Blood levels and urinary excretion of thiamin and riboflavin during oral administration of multivitamin tablets to healthy adults.
    Author: Itokawa Y, Kimura M, Nishino K, Mino M, Kitagawa M, Matsuoka M, Otsuka H.
    Journal: J Nutr Sci Vitaminol (Tokyo); 1992; Spec No():438-41. PubMed ID: 1297784.
    Abstract:
    1. The baseline blood thiamin concentration increased gradually during the long-term administration of TTFD, and the blood concentration was dose-dependent. The cumulative urinary thiamin excretion showed the same dose-dependence as the blood concentration. 2. The baseline blood riboflavin concentration also increased steadily during the administration period, but the increase was less than that of thiamin. Dose-dependence of the cumulative urinary excretion of riboflavin was noted. 3. No side effect were observed.
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