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  • Title: Effects of cimetidine and atropine sulfate on gastric secretion and healing of gastric and duodenal ulcers in rats.
    Author: Okabe S, Takeuchi K, Murata T, Takagi K.
    Journal: Eur J Pharmacol; 1977 Jan 21; 41(2):205-8. PubMed ID: 12989.
    Abstract:
    Cimetidine, a new histamine H2-receptor antagonist (50 or 100 mg/kg) and atropine sulfate (15 mg/kg) given intraduodenally, markedly inhibited gastric secretion in pylorus-ligated rats. Cimetidine (100 or 200 mg/kg/day) given for 10 or 12 consecutive days orally in two divided doses, significantly promoted the healing rate of both gastric and duodenal ulcers induced in rats. Atropine (30 mg/kg/day) also significantly accelerated the healing of duodenal ulcers but failed to affect gastric ulcers.
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