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  • Title: Electron microscopy of bone response to titanium cylindrical screw-type endosseous dental implants.
    Author: Steflik DE, Parr GR, Sisk AL, Hanes PJ, Lake FT.
    Journal: Int J Oral Maxillofac Implants; 1992; 7(4):497-507. PubMed ID: 1299646.
    Abstract:
    This study investigated the undecalcified bone and enveloping tissues supporting commercially pure titanium one-stage and two-stage endosseous dental implants placed into the mandibles of adult mongrel dogs. Correlative light microscopy, transmission electron microscopy, and high-voltage transmission electron microscopy demonstrated a dynamic bone interface to the implants. Mineralized tissue was routinely observed within 20 to 50 nm from the implant interface, separated from the implant interface only by an electron-dense deposit. The densely mineralized collagen fiber matrix was oriented parallel to the implant interface, as were osteocytes that were found close to the interface. Osteocytic projections progressed through canaliculi, often directly to the implant interface. Unmineralized areas that appeared to have the potential for mineralization were also identified.
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