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  • Title: Fecal alpha 1-antitrypsin clearance in the differential diagnosis of steatorrhea.
    Author: Bai JC, Sugai E, Morán C, Sambuelli A, Vázquez H, Mazure R, Boerr L, Mackenzie D.
    Journal: Acta Gastroenterol Latinoam; 1992; 22(2):95-8. PubMed ID: 1300854.
    Abstract:
    We reviewed the fecal fat excretion and alpha 1-antitrypsin clearance results of 160 patients with steatorrhea in whom a final diagnosis was obtained, based on history, physical examination, and radiological, functional and morphological tests. Twenty-two patients had pancreatic diseases and 138 had steatorrhea due to gastrointestinal diseases. alpha 1-antitrypsin clearance was invariably normal in chronic pancreatitis, but there was only a 23 to 50% of correct etiological classification when the combination of steatorrhea and normal alpha 1-antitrypsin clearance was present. However, none of our patients diagnosed of chronic pancreatitis had abnormal alpha 1-antitrypsin clearance. The combination of steatorrhea and normal clearance of alpha 1-antitrypsin was a modest clue for diagnosis of pancreatic malabsorption.
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