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  • Title: A biochemical study of short-cycle manic-depressive psychosis in mental defectives.
    Author: Naylor GJ, Reid AH, Dick DA, Dick EG.
    Journal: Br J Psychiatry; 1976 Feb; 128():169-80. PubMed ID: 130181.
    Abstract:
    Four mentally defective patients who were suffering from short-cycle manic-depressive psychosis were each studied under metabolic ward conditions for about six months. Weekly estimations of erythrocyte Na-K ATPase activity, ouabain sensitive potassium influx, sodium concentration, whole blood cell ATP concentration and blood haematocrit were made. The findings in each patient differed, but the erythrocyte Na-K ATPase activity, sodium and ATP concentration appeared to show cyclic changes related to, though out of phase with, the clinical state.
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