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Title: Studies in relation to endocrine exophthalmos: the biochemical composition of human retrobulbar connective tissue. Author: Singh AP, Nikiforuk M. Journal: Experientia; 1976 Mar 15; 32(3):395-6. PubMed ID: 130249. Abstract: As part of studies on the pathogenesis of exophthalmos of Graves' disease, the biochemical composition of human retrobulbar tissue was investigated. The connective tissue was composed of 72.7% lipid, 23.8% water and 3.5% dried defatted tissue. Total tissue glycosaminoglycan (GAG) amounted to 0.18% of dried defatted tissue. Approximately 27% of the total hexosamine and 19% of the total tissue galactosamine were recovered in the GAG fraction. Cellulose microcolumn fractionation of GAG showed that the hyaluronic acid and dermatan sulfate were the two major GAG species.[Abstract] [Full Text] [Related] [New Search]