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  • Title: [Noradrenaline metabolism in the brain of young rats during formation of inherited stress-induced arterial hypertension].
    Author: Gordienko NI, Maslova LN, Markel' AL, Naumenko EV.
    Journal: Patol Fiziol Eksp Ter; 1992; (5-6):3-5. PubMed ID: 1302823.
    Abstract:
    The noradrenaline (NA) metabolism rate was studied in discrete brain areas of young rats with inherited stress-induced arterial hypertension (ISIAH rats) in the period of rapid hypertension formation (4th week, 22nd-23rd days of life). The rate of metabolism was evaluated according to the NA concentration regression lines after inhibition of tyrosine hydroxylase oridopamine-beta-hydroxylase. The level of NA and the rate of its metabolism in the posterior hypothalamus, midbrain, and pons were higher in ISIAH rats than in normotensive Wistar rats. These parameters in the frontal cortex, anterior hypothalamus, and medulla oblongata were the same in the two rat strains. The possible role of NA metabolic changes in the development of inherited arterial hypertension is discussed.
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