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  • Title: GTP-binding proteins in bovine brain nuclear membranes.
    Author: Otto H, Buchner K, Beckmann R, Hilbert R, Hucho F.
    Journal: Neurochem Int; 1992 Oct; 21(3):409-14. PubMed ID: 1303165.
    Abstract:
    Nuclear membranes and other subcellular fractions derived from bovine brain cortex were investigated for the existence of GTP-binding proteins. By using photolytic labeling with [alpha-32P]GTP a 29 kDa GTP-binding protein was shown to be present in nuclear membranes which was not present in the plasma membranes nor in microsomal or cytosolic fractions. Two-dimensional gel electrophoresis revealed that this protein is rather acidic with a pI lower than 4.5. Members of the heterotrimeric Gi/o family are not present in the nuclear envelope: a 39 kDa protein, ADP ribosylated by pertussis toxin, was shown to originate from plasma membrane contamination.
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