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  • Title: [In vitro liver microsomal metabolism of antimalarial primaquine].
    Author: Ni YC, Wang MJ, Xu YQ, Hu-Ling.
    Journal: Zhongguo Ji Sheng Chong Xue Yu Ji Sheng Chong Bing Za Zhi; 1992; 10(4):275-8. PubMed ID: 1303335.
    Abstract:
    The profile of the major metabolites of primaquine produced by in vitro liver microsomal metabolism was investigated with silica gel thin-layer and high performance liquid chromatography (HPLC) analysis. The results indicated that the liver microsomal metabolism could simultaneously produce both 5-OH PQ (quinoline ring oxidation product) and CPQ (side-chain oxidative deamination product). However, the quantitative comparative study of microsomal metabolism showed that the production of 5-OH PQ was far much higher than that of CPQ.
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