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  • Title: Antibody deficiency with hyper IgM--a case report.
    Author: Noh LM, Low SM, Lajin I, Abdullah N.
    Journal: Malays J Pathol; 1992 Dec; 14(2):121-3. PubMed ID: 1304625.
    Abstract:
    A 20-month-old Indian boy presented with recurrent pyogenic infections and failure to thrive. His IgG and IgA levels were low, but his IgM was elevated. He also had undetectable isohaemagglutinin titre and neutropenia, both parameters being poor prognostic indicators in this very rare primary immunodeficiency state--antibody deficiency with hyper IgM. Our patient subsequently succumbed to Pseudomonas aeruginosa septicaemia and meningitis inspite of aggressive antibiotic and intravenous gammaglobulin therapy. To the best of our knowledge, this is the first such case to be documented in Malaysia.
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