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  • Title: [Klinefelter's syndrome and leg ulcers: role of blood coagulation disorders].
    Author: Hesse S, Berbis P, Juhan-Vague I, Bonerandi JJ, Privat Y.
    Journal: Ann Dermatol Venereol; 1992; 119(12):951-7. PubMed ID: 1304686.
    Abstract:
    Genetically, Klinefelter's syndrome is characterized by a super-numerary chromosome X in male subjects presenting with clinical and biochemical hypoandrogenism and relative hyperoestrogenism. The association of Klinefelter's syndrome with chronic leg ulcer has given rise to numerous publications. The cause of the trophic disorders is unclear. We report two cases of this syndrome associated with chronic leg ulcers and anomalies of haemostasis. One of these two patients had platelet hyperaggregability followed by disorders of fibrinolysis, while the other had disorders of fibrinolysis. We reviewed the literature concerning the various aetiopathogenic hypotheses put forward to explain the cause of these leg ulcers, as well as their interactions and relationship with the hormonal anomalies. The position occupied by disorders of haemostasis is particularly developed.
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