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  • Title: [Radioprotective action of gas hypoxia (8%) in local irradiation of the kidneys].
    Author: Ostapenko VV, Waĭnson AA.
    Journal: Fiziol Zh (1978); 1992; 38(5):67-9. PubMed ID: 1305086.
    Abstract:
    The radioprotective action of hypoxia in local irradiation of kidneys was studied. The experiments were carried out on hybrid mice (CBA x C57Bl) exposed to local X-ray irradiation through a lead diaphragm matched to the kidneys. In the experimental group the animals breathed in gaseous mixture with 8% of oxygen prior to and during irradiation. 20-36 weeks after irradiation the functions of glomerular and juxtaglomerular systems, as well as mass of native and dried kidneys were studied in the animals. It is shown that hypoxia efficiently protects kidneys against irradiation and permits increasing the supplied dose of radiation at least by 25%. High-efficient protection is retained when passing from single to fractionated irradiation.
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