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  • Title: [The effect of ziksorin on the development of experimental food anaphylaxis in guinea pigs].
    Author: Khlopushina TG, Krinskaia AV, Kovalenko LP, Liubimov BI.
    Journal: Eksp Klin Farmakol; 1992; 55(1):51-3. PubMed ID: 1305437.
    Abstract:
    A study was made of the effect of zixorin, an inductor of liver cytochrome P-450, on the intensity of the immediate type allergic reaction--active food anaphylaxis in response to ovalbumin in guinea-pigs. Intraperitoneal injection of zixorin in a dose of 50 mg/kh for 3 days before administration of the antigen resolution dose was found to lower 2,3-fold the level of lethal outcomes due to the anaphylactic shock. It is suggested that zixorin may be used in multimodality treatment of food allergy.
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