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  • Title: [The effect of hormonal systems on the activity of convulsant agents].
    Author: Sapronov NS.
    Journal: Eksp Klin Farmakol; 1992; 55(5):8-11. PubMed ID: 1305464.
    Abstract:
    The dynamics of convulsive action exerted by Bemegride, 15 mg/kg, and Corasol (Pentamethylenetetrasol, 50 mg/kg, was examined in rat experiments during extirpation of endocrine glands (pituitary, thyroid, adrenals and gonads). Their effects were found to be unequal in various series of experiments: thyroidectomy intensified the nature of convulsive reactions while gonadectomy attenuated them; sex-specific differences in the effects of the agents were insignificant. It has been suggested that the hormone-mediator interaction is essential in the mechanisms of convulsive action of Bemegride and Corasol.
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