These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: [Investigation of factors determining stability of BCG vaccine].
    Author: Janaszek W.
    Journal: Med Dosw Mikrobiol; 1992; 44(3-4):137-44. PubMed ID: 1305917.
    Abstract:
    This study was aimed at establishment of influence of a carrier-sodium glutamate and of changes introduced during the process of freeze-drying on survival of BCG bacilli during lyophilization, as well on thermostability and homogeneity of the vaccine and its immunogenicity. It was found that appropriate drying of the vaccine after freeze-drying performed in higher temperature influences favorably its thermostability. Concentration of the carrier is significantly influential for survival of bacilli during freeze-drying. Vaccine containing 1% of sodium glutamate was characterized by best thermostability, homogeneity and high survival of bacilli during freeze-drying. These parameters were keeping on a high level also one year after expiration date. It was shown that there exists a proportional dependence between immunogenicity of the vaccine measured indirectly by intensiveness of tuberculin allergization and number of live particles of BCG contained in vaccination dose.
    [Abstract] [Full Text] [Related] [New Search]