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  • Title: Circadian changes of cytochrome P-450-dependent monooxygenase system in the rat liver.
    Author: Plewka A, Czekaj P, Kamiński M, Plewka D.
    Journal: Pol J Pharmacol Pharm; 1992; 44(6):655-61. PubMed ID: 1305961.
    Abstract:
    Circadian changes in cytochrome P-450 and cytochrome b5 content and activity of NADPH-cytochrome P-450 and NADH-cytochrome b5 reductases have been studied in rat liver microsomes in season autumn. The obtained results indicate, that cytochrome P-450 in 6-month-old animals shows 12 h rhythm, but in older ones 24 h rhythm. NADPH-cytochrome P-450 reductase activity shows 24 h rhythm in oldest animals only. Cytochrome b5 and its reductase has 24 h rhythm in all examined groups of rats.
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