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  • Title: [Genetic background of bronchial asthma].
    Author: Kawakami Y.
    Journal: Nihon Kyobu Shikkan Gakkai Zasshi; 1992 Dec; 30 Suppl():1-4. PubMed ID: 1306210.
    Abstract:
    Familial aggregations and genes for atopy, airway hyperresponsiveness, and serum IgE were studied in 69 members of five atopic asthmatic families spanning three generations. Atopy was found in 68%, bronchial asthma in 26%, airway hyperresponsiveness in 45%, and positive mite allergen in 59%. Both atopy and airway hyperresponsiveness were inherited in an autosomal dominant fashion, but were not related to each other. No linkage was found of HLA with atopy and mite positivity. T cell gamma receptor gene (7p15), IL-3, IL-4, and IL-5 genes (5q23), and postulated atopic gene (11q13) were all not linked to atopy. However, alle 2.5 kb of 11q13 showed an association with serum IgE level. The beta 2 adrenergic receptor gene (5q31-32) was linked to airway responsiveness to inhaled beta 2 adrenergic agonist, and was associated with the occurrence of bronchial asthma.
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