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  • Title: [Various clonidine drops in treatment of glaucoma].
    Author: Szymański A, Brozyna-Zyłka B, Sobieraj A, Otrzonsek D.
    Journal: Klin Oczna; 1992 Oct; 94(10):289-91. PubMed ID: 1306536.
    Abstract:
    Seventeen patients with glaucoma were given bilaterally a single drop of Isoglaucon (Clonidine hydrochloride) of various volume (15 microliters and 40 microliters) and various concentrations of the drug (0.125%, 0.25%, 0.50%) according to the principle of a double blind trial. In comparison with placebo all sorts of Isoglaucon drops cause a statistically important reduction of intraocular pressure; an essential lowering of the general systolic and diastolic pressure (a side effect of the treatment) appeared after application of a larger drop (40 microliters) of a 0.5% concentration. By reducing the content of the drug in the drop or reducing its volume one can avoid the fall in the general blood pressure.
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