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  • Title: [Lipid and lipoprotein profile in psoriasis].
    Author: Deiana L, Pes GM, Carru C, Tidore M, Cherchi GM.
    Journal: Boll Soc Ital Biol Sper; 1992 Dec; 68(12):755-9. PubMed ID: 1307021.
    Abstract:
    Psoriasis is a common relapsing dermatosis characterized by an increased epidermal cell proliferation. In this work we studied the lipid and lipoprotein pattern in 17 patients affected by long-standing psoriasis and in 20 normal controls. Total cholesterol, triglyceride, HDL-cholesterol and Apolipoprotein AI and B levels were measured; VLDL, LDL and HDL chemical composition was assessed by preparative ultracentrifugation. Plasma lipid and lipoprotein levels were significantly lower in the patient group; chemical analysis of the main lipoprotein classes showed compositional abnormalities consistent with an accelerated turnover of these particles. We believe that epidermal cell proliferation can play a role in determining these changes.
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