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  • Title: [Oxidative phosphorylation in rat skeletal muscles in dynamics of vibration-noise effect].
    Author: Baranova NP.
    Journal: Ukr Biokhim Zh; 1976; 48(1):82-5. PubMed ID: 130705.
    Abstract:
    The effect of vibration (vibration level of 130 dB at a frequency of 2 Hz; 108, 118, and 105 dB at frequencies of 32, 63 and 125 Hz, respectively) combined with the noise at mid- and low-frequencies (sound pressure level of 85 dBA) was studied as applied to oxidative phosphorylation in mitochondria from skeletal muscles of the rats exposed to a single action of the mentioned factors, for a fortnight and for a month. A certain separation of oxidation and phosphorylation was observed after a fortnight action of the studied factors. The expressed changes in the process of oxidative phosphorylation were detected after the vibration-noise effect for a month. A considerable decrease of the P/O coefficient (almost twice as compared to the control one) occurs when oxygen uptake by mitochondria is intensified (1.9 times) and their phosphorylation activity is lower (by 61.5%). This is accompanied by a rise (by 2.65 times) of Mg2+-activated ATPase of mitochondria and by a deficit of adenylic system components (ATP, ADP, AMP) in the muscular tissue homogenate.
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