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  • Title: Antitumor activity of basic fibroblast growth factor-saporin mitotoxin in vitro and in vivo.
    Author: Beitz JG, Davol P, Clark JW, Kato J, Medina M, Frackelton AR, Lappi DA, Baird A, Calabresi P.
    Journal: Cancer Res; 1992 Jan 01; 52(1):227-30. PubMed ID: 1309225.
    Abstract:
    Many cancer cell lines express basic fibroblast growth factor (FGF) receptors, making them potential targets for the delivery of FGF-based cytotoxic compounds. To this end, we have investigated the antitumor activity of a novel mitotoxin, Fibroblast Growth Factor-saporin (FGF-SAP), a conjugate of FGF and the ribosome-inactivating protein, saporin. In vitro, FGF-SAP is cytotoxic for human melanoma, teratocarcinoma, and neuroblastoma cells expressing FGF-receptors. Mice treated with FGF-SAP i.v., on a variety of schedules, showed dramatic tumor growth inhibition with minimal toxicity. Thus, FGF-SAP appears to be a well-tolerated and potent antitumor agent. The potential of FGF-targeted cytotoxicity is discussed.
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