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  • Title: Alaskan malamute chondrodysplasia. II. Urinary excretion of hydroxyproline, uronic acid and acid mucopolysaccharides.
    Author: Hoag GN, Brown RG, Smart ME, Subden RE.
    Journal: Growth; 1976 Mar; 40(1):13-8. PubMed ID: 131054.
    Abstract:
    The urinary excretion of free, total and non-dialyzable hydroxyproline appeared to be similar in both chondrodysplastic and non-chondrodysplastic Alaskan Malamutes of ages six and twenty-six weeks suggesting the metabolic defect was probably not related to a gross disturbance in collagen metabolism. Urinary hexuronic acids also appeared to be similar in levels for both populations. A four-fold increase in urinary mucopolysaccharide levels observed at age twenty-six weeks in the chondrodysplastic Alaskan Malamute suggested a deviation from normal. The magnitude and variability of deviation were not sufficient to indicate that this condition could serve as a model for the mucopolysaccharidosis of man but probably indicated a delayed maturation process.
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