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  • Title: A point mutation within a distinct conserved region of the herpes simplex virus DNA polymerase gene confers drug resistance.
    Author: Hwang CB, Ruffner KL, Coen DM.
    Journal: J Virol; 1992 Mar; 66(3):1774-6. PubMed ID: 1310779.
    Abstract:
    We have shown that a drug-resistant mutant from a clinical isolate of herpes simplex virus contains a single point mutation in the DNA polymerase gene that confers resistance to both acyclovir and foscarnet. The mutated amino acid is located within a distinct conserved region shared among alpha-like DNA polymerases which we designate region VII. We infer that these conserved sequences are directly or indirectly involved in the recognition and binding of nucleotide and PPi substrates.
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