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  • Title: A comparative study on the catalytic properties of guanyl-specific ribonucleases.
    Author: Yakovlev GI, Moiseyev GP, Bezborodova SI, Both V, Sevcik J.
    Journal: Eur J Biochem; 1992 Feb 15; 204(1):187-90. PubMed ID: 1310940.
    Abstract:
    The kinetic parameters of reactions catalyzed by four guanyl-specific RNases T1, Pb1, Th1 and Sa were studied comparatively using three types of substrates; guanosine-2',3'-cyclophosphates, GpN dinucleoside phosphates and synthetic polyribonucleotides. The kinetic parameters were shown to be similar in spite of considerable differences in primary structures of these RNases, including amino acid residues of the active sites. Therefore, primary structures of guanyl RNases allow for a considerable number of substitutions (both in the 'recognising' and catalytical parts of the active site) without changes in the catalytical parameters.
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