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  • Title: Alteration of a DNA-dependent ATPase activity in xeroderma pigmentosum complementation group C cells.
    Author: Yanagisawa J, Seki M, Ui M, Enomoto T.
    Journal: J Biol Chem; 1992 Feb 25; 267(6):3585-8. PubMed ID: 1310977.
    Abstract:
    DNA-dependent ATPase activities in crude extracts prepared from HeLa cells were separated into five peaks by fast protein liquid chromatography Mono Q column chromatography. Similar elution profiles were observed with the extracts from human cells normal in repair and xeroderma pigmentosum cells belonging to complementation groups A through G except for group C. An alteration in elution of one of the five ATPases, designated DNA-dependent ATPase Q1, was observed with a cell line of complementation group C. This alteration was observed with all tested cell lines that belonged to group C. ATPase Q1 in HeLa cell extracts exhibited about 2-fold higher activity with ultraviolet light-irradiated DNA as compared to that with non-irradiated DNA, whereas little difference in the effects of two DNAs was observed with the ATPase activities in the extract from group C cells.
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