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  • Title: In vivo potentiation of atracurium neuromuscular blockade by nimodipine in rabbits.
    Author: Gómez-Iglesias E, García E, Suarez E, Martínez R, Rodríguez-Sasiaín JM, Calvo R.
    Journal: Acta Anaesthesiol Scand; 1992 Jan; 36(1):67-9. PubMed ID: 1311493.
    Abstract:
    The interaction between nimodipine, a calcium channel blocker, used for the treatment of subarachnoid haemorrhage, and atracurium, was studied in rabbits. An intravenous dose of 0.1 mg.kg-1 of nimodipine given over 3 min caused a potentiation of the neuromuscular blocking action of atracurium (administered at an infusion rate of 7.5 micrograms.kg-1.min-1), measured on the indirectly stimulated tibialis-anterior muscle of the animal. (ED50)inf and (ED95)inf were significantly reduced (30.7% and 23.3%) in nimodipine-treated animals (P less than 0.05 and P less than 0.02, respectively). No changes were observed in recovery rate.
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