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  • Title: Okadaic acid inhibits phosphatidylethanolamine biosynthesis in rat hepatocytes.
    Author: Tijburg LB, Vermeulen PS, Schmitz MG, van Golde LM.
    Journal: Biochem Biophys Res Commun; 1992 Feb 14; 182(3):1226-31. PubMed ID: 1311568.
    Abstract:
    Okadaic acid, a specific inhibitor of protein phosphatase 1 and 2A, inhibited the synthesis of phosphatidylethanolamine via the CDPethanolamine pathway in isolated hepatocytes. Pulse-chase experiments and measurement of the enzyme activity demonstrated that the inhibition of phosphatidylethanolamine synthesis was not caused by an inhibition of CTP:phosphoethanolamine cytidylyltransferase, the putative regulatory enzyme. However, okadaic acid decreased the cellular diacylglycerol level to 30% of that in control cells. The data suggest that the availability of diacylglycerol limits phosphatidylethanolamine synthesis in okadaic acid-treated hepatocytes.
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