These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Twenty-four year spironolactone therapy in an aged patient with aldosterone-producing adenoma.
    Author: Takeda R, Yamazaki T, Ito Y, Koshida H, Morise T, Miyamori I, Hashimoto T, Morimoto S.
    Journal: Acta Endocrinol (Copenh); 1992 Feb; 126(2):186-90. PubMed ID: 1311894.
    Abstract:
    A case of primary aldosteronism treated with spironolactone therapy has been followed up for 24 years. This is probably the longest case of spironolactone therapy for primary aldosteronism that has ever been reported. Long-term treatment with spironolactone controlled the hypertension and prevented hypokalemic alkalosis in this patient, without any deleterious effects on steroid biosynthesis. Based on data obtained during dose reduction and subsequent withdrawal of spironolactone, it is suggested that the suppressed plasma renin activity associated with adenoma-induced aldosteronism develops prior to hypokalemia and hypertension.
    [Abstract] [Full Text] [Related] [New Search]