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  • Title: Development of hepatocellular carcinoma in a man with auto-immune chronic active hepatitis.
    Author: Yousuf M, Kiyosawa K, Sodeyama T, Yoda H, Nakano Y, Furuta S.
    Journal: J Gastroenterol Hepatol; 1992; 7(1):66-9. PubMed ID: 1311968.
    Abstract:
    A 57 year old man with auto-immune chronic active hepatitis, regularly treated with immunosuppressive therapy, had hepatocellular carcinoma (HCC) 10 years after diagnosis of the hepatitis. Assays of the hepatitis C virus antibodies against capsid and non-structural proteins revealed seronegativity in serial serum samples of this patient stored in the previous 10 years during follow up. The seronegative hepatitis C antibodies excluded hepatitis C virus as the cause of the HCC. The occurrence of HCC in this case suggests the necessity of surveillance for early detection of liver cancer in patients with auto-immune chronic active hepatitis undergoing long-term immunosuppressive therapy.
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