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  • Title: Control of invasive pulmonary aspergillosis with oral itraconazole in a bone marrow transplant patient.
    Author: Denning DW, Stepan DE, Blume KG, Stevens DA.
    Journal: J Infect; 1992 Jan; 24(1):73-9. PubMed ID: 1312563.
    Abstract:
    Pulmonary aspergillosis following bone marrow transplantation carries a mortality of 94%, irrespective of current treatment. We treated a patient who had acquired aspergillosis some 80 days after allogeneic bone marrow transplantation, with oral itraconazole, 600 mg daily. After initial deterioration, clinical and radiographic resolution occurred during 3 months of therapy despite severe graft-vs.-host and cytomegalovirus disease. Itraconazole should be considered for therapy of pulmonary aspergillosis in this and other immunocompromised settings.
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