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  • Title: Artemisinin derivatives bearing Mannich base group: synthesis and antimalarial activity.
    Author: Li Y, Yang ZS, Zhang H, Cao BJ, Wang FD, Zhang Y, Shi YL, Yang JD, Wu BA.
    Journal: Bioorg Med Chem; 2003 Oct 01; 11(20):4363-8. PubMed ID: 13129573.
    Abstract:
    Novel artemisinin derivatives bearing Mannich base group were prepared and tested for their antimalarial activity. These water-soluble artemisinin derivatives were more stable than sodium artesunate and few compounds were found to be more active against Plasmodium berghei in mice than artesunic acid by oral administration. Two most potent derivatives 17b and 17d were examined for their antimalarial activity against Plasmodium knowlesi in rhesus monkeys.
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