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  • Title: [Excretion of erythropoietin by humans during the production of alkaline or acidic urine (author's transl)].
    Author: Cissée H, Schultz VE.
    Journal: J Clin Chem Clin Biochem; 1976 Dec; 14(12):557-9. PubMed ID: 13138.
    Abstract:
    Marver & Gurney ((1968)Ann.N.Y.Acad.Sci. 149, 570-575) reported that the erythropoietin excretion in two anaemic patients increased 17 and 3.5-fold, respectively, during the production of alkaline urine by the administration of NaHCO3. We have studied the excretion of erythropoietin in 6 persons, following the daily administration of 3.5 g of NH4Cl, which resulted in an average urine pH of 5.9; and following the administration of hexapotassium hexasodium pentacitrate, which increased the urine pH TO 7.5. In the alkaline urine, erythropoietin excretion showed an average, but non-significant, two-fold increase. The increase was significant in only two experimental persons.
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